Market need and potential
Our innovative approach address two unmet clinical needs in cancer management; to reduce cancer-induced cachexia and promote reactivation of the immune system.
Even in a patient with low tumor burden, cancer can trigger processes that both can lead to immune-suppression and induction of cancer cachexia, which will ultimately lead to death if the symptoms cannot be reversed.
Both the suppression of the immune system and the management of cachectic patients are major clinical challenges, where unwanted weight loss (cachexia) is a problem without any therapeutic options and accounts for more than 15 % of all cancer deaths. On the other hand, immune reactivators, like PD1/PDL1 targeted therapies have been blockbusters, but due to high therapy costs and inadequate companion diagnostics, they have limit use.
In our approach, our novel chemical entities (NCE) can affect both these processes by preventing over activation of underlying signaling pathways. The NCE are modeled based on existing pharmaceuticals that are well tolerable and easy to produce, thereby offering a cost-effective therapeutic compound.
Treatments targeting the immune system, promoting the patient’s own healing capacity, are often considered the future of cancer treatment.
We will via a once-daily pill offer increased survival, improved quality of life and less suffering for many cancer patients. This will be a first in class drug with little side effects (known drug class), addressing cancer-induced cachexia and suppression of the immune system.