Fredrik Elgh and Jonathan Gilthorpe identified a novel antiviral activity against the herpes virus that targets the early stages of viral infection. They have explored this further to develop an antiviral drug that can be used to treat herpes virus infections more efficiently and help overcome antiviral resistance.
Current drugs against mycoses are toxic. We aim to develop a new class of antifungal agents that disarm the invasive forms of fungal cells instead of merely eradicating them. This has two advantages: The new compounds are less aggressive for the host and resistance development is reduced.
Obesity is a serious and increasing worldwide problem. Inhibition of the appetite-stimulating factors would be a possible treatment for obesity. This discovery provides a target for possible drug intervention for limiting food intake among the obese. Today the hypothesis still holds and three drug companies have been formed.